Natural Compounds Activating the AMPK/SIRT1pathway a Therapeutic Potential for Non-Alcoholic Fatty Liver Disease

Natural Compounds Activating the AMPK/SIRT1pathway a Therapeutic Potential for Non-Alcoholic Fatty Liver Disease

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Lipid accumulation in the liver is associated with non-alcoholic fatty liver disease (NAFLD), with obesity and insulin resistance being the main contributing factors.The AMPK/SIRT1 signaling pathway plays a crucial role in addressing lipid citronella horse shampoo metabolism issues.Recent studies have demonstrated that the AMPK/SIRT1 signaling axis is involved in preventing and reducing liver damage.Upregulation of AMPK/SIRT1 can regulate lipid metabolism and oxidation in liver cells.In NAFLD, increased activity of AMPK/SIRT1 can inhibit the synthesis of fatty acids and cholesterol by down-regulating adipogenesis genes (FAS, SREBP-1c, ACC, and HMGCR).

Therefore, activation of the AMPK/SIRT1 signaling pathway represents a potential therapeutic target for liver disorders.This review summarizes the read more most recent studies on the AMPK/SIRT1 pathway signaling axis and the mechanisms of herbal activators of the AMPK/SIRT1 pathway in non-alcoholic fatty liver.